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Personal:
Eng. JOSE ENRIQUE BRITO LEON
Age: 40, married, 3 kids
Academical degree: Chemical Engineer, 1984, "José A. Echeverría" Polytechnical Institute.
Working experience: 18 years
Biological Research Center (CIB) from 1984 to 1986
Genetic Engineering and Biotechnology Center (CIGB) from 1986 to 2002
Current position: Deputy director for Production Working areas:
Packaging Development
Process Development and scale-up
Cloning and others molecular biology related techniques
Process Economic evaluation
Business analysis and Development
Pharmaceuticals Production management
Production of Restriction and Modification Enzymes
Inmunologicals Techniques
Other responsibilities:
Professor at the Production Basic Course
Member of the Directive Board at CIGB
Head of the Technical Reports Committee
Member of the Scientific Council at CIGB
Member of the Production Advising Council
External member of the National Pharmaceutical Industry Scientific council
Member of the expert team at the National Program of Biotechnology and Pharmaceuticals (Science and Technology Ministery (CITMA)
Publications:
Purification of a thermostable DNA Polymerase from Thermus thermophilus HB 8, useful in the Polymerase Chain Reaction. Biotechniques Vol 9, No. 3 (1990), pag 276
Purificación de la enzima de Restricción Sma I. Biotecnología Aplicada, vol 7, No. 3 (1990) pag 326
Niveles de producción de Interferon Alfa-2 recombinante por células de Saccharomyces cerevisiae libres e inmovilizadas., Biotecnología Aplicada, vol 7, No. 1 (1990) pag 87
Searching for replication origins in mammalian GENE 135 (1993) pag 125-135.
Autoantibodies to Human Nuclear Lamin B2 Protein, Epitope specificity in different autoimmune diseases, The Journal of Immunology, 153 (1994) pag 2268
Cloning and expression of gene coding for Haemophilus influenzae Rf restriction and modification enzymes, Purification of the recombinant endonuclease, Biotecnología Aplicada, vol 12, No. 3 (1995)
Validation of Radiactive Methods in the Quality Control of DNA Restriction Enzymes. Biotecnología Aplicada, Vol 13 No. 3 (1996) pag 197-200
Purification of the restriction endonuclease Sac I free of Sac II and Sac III contaminants. Biotecnología Aplicada. Vol 13, No.4 (1996)
Establecimiento de un Proceso para la obtención de Proteina A, partiendo de una cepa de Escherichia coli Recombinante. Biotecnología Aplicada, vol 13, No. 3 (1996) pag 207
Single-chain Fv antibody fragment for the immunoaffinity purification of a recimbi-nant hepatitis B virus surface antigen particle. Minerva Biotechnologica, 9: 68-75 1997
Proceso de purificación de polipéptidos multiepitopicos (MEPS). 48/98 Cuban Patent office (1998)
Detection of Deoxyribonuclease activities using a PCR-Generated radiolabeled DNA substrate. Biotecnología Aplicada; Vol.1 (1999) pag.29-30
Estudio de estabilidad de la vacuna antihepatitis B con bajo porciento de timerosal almacenada en sistema Uniject. Technical Report (2001)
Evaluación y desarrollo de tecnologías novedosas de envase de productos farmacéuticos. Technical Report (2002)
Valoración del dispositivo Uniject para el envase de la vacuna antihepatitis B. Technical Report (2002)
Desarrollo de la presentación en jeringuillas prellenadas de la vacuna antihepatitis B. Technical Report (2002)
Proyecto de construcción de la planta de desarrollo de nuevos productos biofarmacéuticos (Planta 4). Technical Report (2002)
Language knowledge: English and Italian |
